Profiling of Peripheral TRBV and CD4+CD25+ Treg in CHB Patients with HBeAg SC during TDF Treatment

Figure 3

Association between the number of skewed TRBV families and the HBV DNA load or ALT level in HBeAg seroconverting (SC) or non-SC subjects during TDF treatment. The relationship between the HBV DNA level (log10 copies/mL) and the number of skewed TRBV families is shown for HBeAg SC (a) and non-SC subjects (b). The relationship between the ALT level (U/L) and the number of skewed TRBV families is shown for HBeAg SC (c) and non-SC subject (d). The -axis indicates the different treatment time points; (a) and (b) on the left -axis show the HBV DNA levels; (c) and (d) on the left -axis show the ALT levels, and the right -axis shows the number of skewed TRBV families. Correlations were analyzed using a Spearman correlation analysis.

(a)

(b)

(c)

(d)