miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression

Figure 6

miR-1 inhibited OA progression in experimental OA model. (a) Representative images of safranin O/fast green staining and toluidine blue staining for mice joint after intra-articular injection of Agomir-1. Scale bar = 200 µm. (b) Representative images of immunofluorescence staining of Col2, aggrecan and MMP13 for mice joint after intra-articular injection of Agomir-1. Scale bar = 100 µm. (c) OARSI score for assessing arthritis severity. (d) Quantitative analysis of immunofluorescence staining of Col2, aggrecan and MMP13 for mice joint. (e) Representative images of immunohistochemical staining of GPX4. Scale bar = 100 µm. (f) Analysis of the percentage of GPX4-positive cells. Data were presented as the mean ± SD of at least three replicates. , and .

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