Research Article
Interferon-Induced Transmembrane Protein 3 rs34481144 C/T Genotype and Clinical Parameters Related to Progression of COVID-19
Table 2
IFITM3 rs34481144 association with COVID-19 mortality.
| | | Groups | | | | | | Model | Genotype | Recovered patients | Deceased patients | OR (95% CI) | P-value | AIC | BIC |
| | Allele | C | 2,349 (88.0%) | 1,915 (83.0%) | 1.00 | – | – | – | | T | 335 (12.0%) | 383 (17.0%) | 1.98 (1.32–2.86) | | – | – |
| | Codominant | C/C | 1,019 (75.9%) | 782 (68.1%) | 1.00 | | 3,423.2 | 3,434.8 | | C/T | 311 (23.2%) | 351 (30.6%) | 1.47 (1.23–1.76) | | T/T | 12 (0.9%) | 16 (1.4%) | 1.74 (0.82–3.69) |
| | Dominant | C/C | 1,019 (75.9%) | 782 (68.1%) | 1.00 | | 3,425.9 | 3,442.5 | | C/T-T/T | 323 (24.1%) | 367 (31.9%) | 1.48 (1.24–1.77) |
| | Recessive | C/C-C/T | 1,330 (99.1%) | 1,133 (98.6%) | 1.00 | 0.24 | 3,440.9 | 3,452.6 | | T/T | 12 (0.9%) | 16 (1.4%) | 1.57 (0.74–3.32) |
| | Overdominant | C/C-T/T | 1,031 (76.8%) | 798 (69.5%) | 1.00 | | 3,425.1 | 3,436.7 | | C/T | 311 (23.2%) | 351 (30.6%) | 1.46 (1.22–1.74) |
| | Minor allele frequency (T) | 0.12 | 0.17 | – | – | – | – |
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IFITM3, interferon-induced transmembrane protein 3; OR, odds ratios; CI, confidence intervals; AIC, Akaike information criterion; BIC, Bayesian information criterion. Statistically significant (<0.05). |
