The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome

Figure 1

IL-33 and ST2 levels in the liver and spleen of mice 10 days after the model. (a) Flow chart of MAS model induced by repeated CpG in mice. (b) Body weight changes in control mice and mice repeatedly stimulated with CpG. (c) The expression of IL-33 in the liver of control mice and mice was repeatedly stimulated with CpG (bar = 50 μm). (d) The expression of IL-33 in the control mice and mice spleen was repeatedly stimulated with CpG (bar = 50 μm). (e) The expression of ST2 in the liver of control mice and mice was repeatedly stimulated with CpG (bar = 50 μm). (f and g) IL-33 positive cells at high magnification in the liver and spleen of control mice and mice repeatedly stimulated with CpG. (h) The mean optical density of ST2 in the liver of control mice and mice repeatedly stimulated with CpG. (i and j) IL-33 and ST2 transcription levels in control mice and mice spleen were repeatedly stimulated with CpG. (k and l) IL-33 and ST2 transcription levels in the liver of control mice and the CpG-stimulated mice. , , .

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