Differences in the Clinical Characteristics and 1-Year Mortality Rates of Patients with Dermatomyositis with anti-Jo-1 and anti-MDA5 Antibodies

Table 1

Univariate analysis comparing the clinical characteristics of the anti-Jo-1 Abs and anti-MDA-5 Abs groups.

	Anti-Jo-1 positive ()	Anti-MDA-5 positive ()	value
Age at diagnosis (yrs)			0.068
Female, (%)	21 (70%)	5 (62.5%)	0.685
Onset (<6mon)	24 (80%)	7 (87.5%)	0.627
ILD, (%)	15 (65.2%)	7 (87.5%)	0.232
RP-ILD, (%)	0 (0%)	6 (75%)	<0.001
HRCT pattern, (%)
None	15 (50%)	1 (12.5%)	0.036
NSIP	8 (26.7%)	1 (12.5%)
UIP	1 (3.3%)	2 (25%)
Ground glass	6 (20%)	4 (50%)
Cardiac involvement	3 (13%)	0 (0%)	0.314
Fever	6 (26.1%)	6 (85.7%)	0.005
Muscle weakness	13 (56.5%)	6 (85.7%)	0.161
Heliotrope rash	2 (8.7%)	5 (71.4%)	0.001
Gottron’s sign	11 (47.8%)	7 (100%)	0.014
Photosensitivity	0 (0%)	6 (85.7%)	<0.001
Cutaneous necrosis	0 (0%)	5 (71.4%)	<0.001
Mechanic hand	13 (56.5%)	6 (85.7%)	0.161
Periungual erythema	3 (13%)	5 (71.4%)	0.002
Auricular papules	0 (0%)	2 (28.6%)	0.008
Raynaud’s phenomenon	5 (21.7%)	2 (28.6%)	0.708
Cutaneous vasculitis	0 (0%)	2 (28.6%)	0.008
Hoarseness	0 (0%)	3 (42.9%)	0.001
Dysphagia	1 (4.3%)	2 (28.6%)	0.061
Polyarthritis	21 (91.3%)	5 (71.4%)	0.176
Positive ANA	14 (63.6%)	2 (25%)	0.061
Maximal CK (IU/L)			0.579
LDH (U/L)			0.278
Ferritin (ng/mL)			0.570
AST (IU/L)			0.179
ALT (IU/L)			0.233
ESR (mm/hr)			0.930
CRP (mg/L)			0.362
PJP positive, (%)	0 (0%)	3 (37.5%)	0.002
Pneumothorax, (%)	0 (0%)	4 (50%)	<0.001
Hypertension	7 (23.3%)	1 (12.5%)	0.504
Diabetes mellitus	11 (36.7%)	8 (100%)	0.001
Respiratory failure, (%)	3 (13%)	5 (62.5%)	0.006
Mortality, (%)	2 (8.7%)	5 (62.5%)	0.002
Survival time (year)			0.014

Anti-MDA5: anti–melanoma differentiation-associated protein 5; ANA: antinuclear antibody; AST:aspartate aminotransferase; ALT: alanine transaminase; CK: creatine phosphokinase; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; HRCT: high-resolution computed tomography; ILD: interstitial lung disease; NSIP: nonspecific interstitial pneumonia; PJP: Pneumocystis jirovecii pneumonia; RP-ILD; rapid progressive interstitial lung disease; yrs: years; UIP: usual interstitial pneumonia. .