Identification of Adipogenesis Subgroups and Immune Infiltration Characteristics in Diabetic Peripheral Neuropathy

Table 1

Hub genes and their functions.

Gene symbol	Full name	Function
PPARG	Peroxisome proliferator-activated receptor gamma	The protein encoded by this gene is PPARγ, which is a regulator of adipocyte differentiation.
FABP4	Fatty acid binding protein 4	FABP4 encodes the fatty acid binding protein binding long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs’ roles include fatty acid uptake, transport, and metabolism.
LIPE	Lipase E, hormone sensitive type	The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
FASN	Fatty acid synthase	Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
SCD	Stearoyl-CoA desaturase	This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid.
DGAT2	Diacylglycerol O-acyltransferase 2	It catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long-chain fatty acyl-CoAs.
PNPLA2	Patatin-like phospholipase domain-containing 2	This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
ADIPOQ	Adiponectin, C1Q, and collagen domain containing	The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency.
LEP	Leptin	This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis.
CEBPA	CCAAT enhancer-binding protein alpha	Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis.