sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway

Figure 1

sNASP mutation promotes LPS-induced proinflammatory cytokine production in B6.lpr mice. The expression of mRNA ((a)–(c) and (g)–(i)) and protein ((d)–(f) and (j)–(k)) of IL-6 and TNF-α were measured by qPCR and ELISA in peritoneal macrophages, compared between B6.lpr and B6.∆sNASP.lpr mice. Following 0/0.5/1/2 hr stimulation with ((a), (d), (g), (j)) LPS 1 ng/ml, ((b), (e), (h), (k)) LPS 10 ng/ml, and ((c), (f), (i), (l)) LPS 100 ng/ml. Data were shown as means ± SEM (n = 3) of one representative experiment. , .

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