sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway

Figure 4

sNASP mutation promotes TLR4-induced NF-κB and MAPK activation of the pathways in B6.lpr mice. The expression of phosphorylated and total proteins was measured by western blotting in peritoneal macrophages and compared between B6.lpr and B6.∆sNASP.lpr mice, and mouse β-actin was used as control. Following 0/0.5/1/2 hr stimulation with (a) LPS (1 ng/ml), (b) LPS (10 ng/ml), (c) LPS (100 ng/ml). Data were shown as means ± SEM. , ; independent sample t-test. Results shown are representative of 2–3 independent experiments.

(a)

(b)

(c)