sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway

Figure 7

Model of TLR4 signaling pathway regulated by sNASP. sNASP mutation promotes LPS-induced TLR4–TAK1 activation in peritoneal macrophages and has no influence on TLR4–TBK1, resulting in the activation of NF-κB and MAPK signaling pathways and the expression of proinflammatory cytokines.