Research Article
Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy
Table 2
The diagnostic value of each activation index in PB for ATB.
| | Variables | AUC
(95% CI) | Youden indicator | Cutoff value | Sensitivity
(95% CI) | Specificity
(95% CI) | PPV
(95% CI) | NPV
(95% CI) | Accuracy (%) |
| | ATB vs. NTB | | CD25+ | 0.88
(0.82–0.95) | 0.6 | 0.9 | 86.7%
(72.5%–94.5%) | 74.0%
(59.4%–84.9%) | 75.0%
(60.8%–85.5%) | 86.0%
(71.4%–94.2%) | 80.0 | | CD69+ | 0.84
(0.76–0.92) | 0.6 | 2.4 | 86.7%
(72.5%–94.5%) | 76.0%
(61.5%–86.5%) | 76.5%
(62.2%–86.8%) | 86.4%
(72%–94.3%) | 81.1 | | CD134+ | 0.89
(0.81–0.96) | 0.7 | 1.4 | 84.4%
(69.9%–93.0%) | 86.0%
(72.6%–93.7%) | 84.4%
(69.9%–93%) | 86.0%
(72.6%–93.7%) | 85.3 | | CD25+CD69+ | 0.88
(0.81–0.95) | 0.7 | 0.4 | 86.7%
(72.5%–94.5%) | 80.0%
(65.9%–89.5%) | 79.6%
(65.2%–89.3%) | 87.0%
(73.1%–94.6%) | 83.2 | | CD25+CD134+ | 0.93
(0.87–0.99) | 0.8 | 0.6 | 86.7%
(72.5%–94.5%) | 94.0%
(82.5%–98.4%) | 92.9%
(79.5%–98.1%) | 88.7%
(76.3%–95.3%) | 90.5 | | CD69+CD134+ | 0.91
(0.85–0.97) | 0.7 | 0.9 | 86.7%
(72.5%–94.5%) | 86.0%
(72.6%–93.7%) | 84.8%
(70.5%–93.2%) | 87.8%
(74.5%–94.9%) | 86.3 | | ATB vs. HC | | CD25+ | 0.84
(0.76–0.93) | 0.7 | 0.8 | 86.7%
(72.5%–94.5%) | 78.6%
(62.8%–89.2%) | 81.3%
(66.9%–90.6%) | 84.6%
(68.8%–93.6%) | 82.8 | | CD69+ | 0.84
(0.75–0.93) | 0.7 | 2.3 | 86.7%
(72.5%–94.5%) | 78.6%
(62.8%–89.2%) | 81.3%
(66.9%–90.6%) | 84.6%
(68.8%–93.6%) | 82.8 | | CD134+ | 0.82
(0.72–0.92) | 0.7 | 1.1 | 88.9%
(75.2%–95.8%) | 76.2%
(60.2%–87.4%) | 80.0%
(65.9%–89.5%) | 86.5%
(70.4%–94.9%) | 82.8 | | CD25+CD69+ | 0.83
(0.74–0.92) | 0.7 | 0.5 | 84.4%
(69.9%–93%) | 83.3%
(68.0%–92.5%) | 84.4%
(69.9%–93%) | 83.3%
(68.0%–92.5%) | 83.9 | | CD25+CD134+ | 0.85
(0.75–0.94) | 0.7 | 0.6 | 86.7%
(72.5%–94.5%) | 83.3%
(68.0%–92.5%) | 84.8%
(70.5%–93.2%) | 85.4%
(70.1%–93.9%) | 85.1 | | CD69+CD134+ | 0.83
(0.74–0.93) | 0.7 | 0.9 | 86.7%
(72.5%–94.5%) | 83.3%
(68.0%–92.5%) | 84.8%
(70.5%–93.2%) | 85.4%
(70.1%–93.9%) | 85.1 | | ATB vs. LTBI | | CD25+ | 0.63
(0.51–0.74) | 0.3 | 4.4 | 31.1%
(18.6%–46.8%) | 100.0%
(89.1%–100.0%) | 100.0%
(73.6%–100.0%) | 56.3%
(44.1%–67.9%) | 56.8 | | CD69+ | 0.65
(0.53–0.77) | 0.3 | 8.4 | 44.4%
(30.0%–60.0%) | 90.0%
(75.4%–96.8%) | 83.3%
(61.8%–94.5%) | 59.0%
(45.7%–71.2%) | 59.0 | | CD134+ | 0.64
(0.52–0.76) | 0.3 | 4.4 | 42.2%
(28.0%–57.8%) | 85.0%
(69.5%–93.8%) | 76.0%
(54.5%–89.8%) | 56.7%
(43.3%–69.2%) | 55.8 | | CD25+CD69+ | 0.60
(0.48–0.72) | 0.3 | 2.3 | 35.6%
(22.3%–51.3%) | 92.5%
(79.5%–98.0%) | 84.2%
(59.5%–95.8%) | 56.1%
(43.4%–68.1%) | 55.8 | | CD25+CD134+ | 0.62
(0.50–0.74) | 0.2 | 1.9 | 35.6%
(22.3%–51.3%) | 87.5%
(72.4%–95.3%) | 76.2%
(52.5%–90.9%) | 54.7%
(41.8%–70.0%) | 53.7 | | CD69+CD134+ | 0.56
(0.44–0.69) | 0.2 | 5.7 | 26.7%
(15.1%–42.2%) | 95.0%
(81.8%–99.1%) | 85.7%
(56.2%–97.5%) | 53.5%
(41.4%–65.3%) | 52.6 |
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Note: PPV = positive predictive value; NPV = negative predictive value; PB = peripheral blood; ATB (n = 45) = active tuberculosis; LTBI (n = 40) = latent tuberculosis infection; NTB (n = 50) = nontuberculosis; HC (n = 42) = healthy control.
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