Research Article
Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy
Table 3
The diagnostic efficacy of activation indexes and routine laboratory methods for ATB diagnosis.
| | Variables | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (%) |
| | Xpert MTB/RIF | 62.2%
(46.5%–75.8%) | 100.0%
(89.6%–100.0%) | 100.0%
(85%–100.0%) | 71.2%
(57.7%–82.0%) | 80.5 | | Acid-fast bacilli smear | 44.4%
(30.0%–59.9%) | 100.0%
(89.6%–100.0%) | 100.0%
(98%–100.0%) | 62.7%
(50.0%–73.9%) | 71.3 | | Mtb culture | 48.9%
(33.9%–64.0%) | 100.0%
(89.6%–100.0%) | 100.0%
(81.5%–100.0%) | 64.6%
(51.7%–75.8%) | 73.6 | | TB-IGRA | 95.6%
(83.6%–99.2%) | 90.5%
(76.5%–96.9%) | 91.5%
(78.7%–97.2%) | 95.0%
(81.8%–99.1%) | 93.1 | | CD25+ | 86.7%
(72.5%–94.5%) | 78.6%
(62.8%–89.2%) | 81.3%
(66.9%–90.6%) | 84.6%
(68.8%–93.6%) | 82.8 | | CD69+ | 86.7%
(72.5%–94.5%) | 78.6%
(62.8%–89.2%) | 81.3%
(66.9%–90.6%) | 84.6%
(68.8%–93.6%) | 82.8 | | CD134+ | 88.9%
(75.2%–95.8%) | 76.2%
(60.2%–87.4%) | 80.0%
(65.9%–89.5%) | 86.5%
(70.4%–94.9%) | 82.8 | | CD25+CD69+ | 84.4%
(69.9%–93.0%) | 83.3%
(68.0%–92.5%) | 84.4%
(69.9%–93%) | 83.3%
(68.0%–92.5%) | 83.9 | | CD25+CD134+ | 86.7%
(72.5%–94.5%) | 83.3%
(68.0%–92.5%) | 84.8%
(70.5%–93.2%) | 85.4%
(70.1%–93.9%) | 85.1 | | CD69+CD134+ | 86.7%
(72.5%–94.5%) | 83.3%
(68.0%–92.5%) | 84.8%
(70.5%–93.2%) | 85.4%
(70.1%–93.9%) | 85.1 |
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