Research Article
Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy
Table 4
Comparison of diagnostic efficacy of PF and PB in the diagnosis of TP.
| | Variables | AUC
(95% CI) | Youden
Indicator | Cutoff
value | Sensitivity
(95% CI) | Specificity
(95% CI) | PPV
(95% CI) | NPV
(95% CI) | Accuracy (%) |
| | PF | | CD25+ | 0.93
(0.86–1.00) | 0.9 | 1.9 | 92.9%
(75.1%–98.8) | 91.7%
(76.4%–97.8%) | 89.7%
(71.5%–97.3%) | 94.3%
(79.5%–99.0%) | 92.2 | | CD69+ | 0.94
(0.87–1.00) | 0.85 | 3.4 | 96.4%
(79.7%–99.8%) | 88.9%
(73.0%–96.4%) | 87.1%
(69.2%–95.8%) | 97.0%
(82.5%–99.8%) | 92.2 | | CD134+ | 0.95
(0.90–1.00) | 0.9 | 2.1 | 96.4%
(79.8%–99.8%) | 88.9%
(73.0%–96.4%) | 87.1%
(69.2%–95.8%) | 97.0%
(82.5%–99.8%) | 92.2 | | CD25+CD69+ | 0.92
(0.85–1.00) | 0.8 | 1.7 | 85.7%
(66.4%–95.3%) | 91.7%
(76.4%–97.8%) | 88.9%
(69.7%–97.1%) | 89.2%
(73.6%–96.5%) | 89.1 | | CD25+CD134+ | 0.95
(0.90–1.00) | 0.9 | 1.3 | 92.9%
(75.0%–98.8%) | 91.7%
(76.4%–97.8%) | 89.7%
(71.5%–97.3%) | 94.3%
(79.5%–99.0%) | 92.2 | | CD69+CD134+ | 0.90
(0.81–0.99) | 0.8 | 2.2 | 85.7%
(66.4%–95.3%) | 91.7%
(76.4%–97.8%) | 88.9%
(69.7%–97.1%) | 89.2%
(73.6%–96.5%) | 89.1 | | PB | | CD25+ | 0.85
(0.75–0.95) | 0.7 | 1.1 | 85.7%
(66.4%–95.3%) | 83.3%
(66.5%–93.0%) | 80.0%
(60.9%–91.6%) | 88.2%
(71.6%–96.2%) | 84.4 | | CD69+ | 0.86
(0.76–0.96) | 0.7 | 2.3 | 89.3%
(70.6%–97.2%) | 77.8%
(60.4%–89.3%) | 75.8%
(57.4%–88.3%) | 90.3%
(73.1%–97.5%) | 82.8 | | CD134+ | 0.86
(0.76–0.96) | 0.7 | 0.9 | 96.4%
(79.8%–99.8%) | 75.0%
(57.5%–87.3%) | 75.0%
(57.5%–87.3%) | 96.4%
(79.8%–99.8%) | 84.4 | | CD25+CD69+ | 0.85
(0.75–0.95) | 0.7 | 0.8 | 85.7%
(66.4%–95.3%) | 83.3%
(66.5%–93.0%) | 80.0%
(60.9%–91.6%) | 88.2%
(71.6%–96.2%) | 84.4 | | CD25+CD134+ | 0.87
(0.78–0.96) | 0.7 | 0.7 | 85.7%
(66.4%–95.3%) | 86.1%
(69.7%–94.8%) | 82.8%
(63.5%–93.5%) | 88.6%
(72.3%–96.3%) | 85.9 | | CD69+CD134+ | 0.87
(0.77–0.97) | 0.7 | 0.7 | 92.9%
(75.0%–98.8%) | 80.6%
(63.4%–91.2%) | 78.8%
(60.6%–90.4%) | 93.6%
(77.2%–98.9%) | 85.9 |
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Note: TP (n = 28) = tuberculous pleurisy; PF = pleural fluid; PB = peripheral blood.
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