Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?

Table 1

Functional effect of single-nucleotide variants (SNVs) on the genes of the inflammasome complex in leukemias.

Gene	Variation	rs	Effect	Key findings	Ref.
NLRP1	c.464 A>T; p. L155H	rs12150220	Increased IL-1ß processing; increased; NLRP1 expression	Protection against infectious diseases in pediatric patients from the Brazilian Amazon with ALL	[94]
NLRP3	c.2113 C>A; p. Q705K	rs35829419	Increased production of IL-1ß and IL-18	Risk of AML in the Asian population	[95]
	N/A	rs4353135		Risk of ALL in the Asian population	[96]
P2X7	A>C; p. Glu496Ala	rs3751143	Loss of function	Longer event-free survival in patients from Sweden with CLL	[97]
CARD8	30T>A; p. C10X	rs2043211	Increased NLRP3, CASP1 and IL-1β transcription	Risk of ALL in the Asian population and T-cell immunophenotype	[98]
CASP8	−652 6N ins/del; −/CTTACT	rs3834129	Decreased production of Caspase-8	Risk of CML in the Asian population	[99]
				Risk of CML and AML in the Iraqi population	[100]
IL1B	c.−511 C>T	rs16944	Increased IL-1β transcription	Risk of developing ALL in children from the Brazilian Amazon	[94]
				Increased transcription of NLRP3 and ASC in ALL in the Asian population	[98]
				Favorable-risk cytogenetics group in AML	[95]
				Increased risk of ALL in Asian children	[96]
IL18	c.−137 G>C	rs187238	Increased IL-18 transcription	Risk of CLL in the Turkish population	[101]
	c.−607 C>A	rs1946518		Increased IL-18 secretion in ALL in an Asian population	[98]
				Risk of pediatric ALL in the Asian population	[96]

Abbreviations: p, protein change; c, changed allele; rs, reference sequence; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CLL, chronic lymphoid leukemia; CML, chronic myeloid leukemia; Ref, references.