Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions

Figure 3

Titers of antibodies against (a) eosinophil peroxidase (anti-EPX), (b) eosinophil cationic protein (anti-ECP), (c) eosinophil-derived neurotoxin (anti-EDN), and (d) myeloperoxidase (anti-MPO) as determined by ELISA at study inclusion. The antibody titers are expressed as arbitrary units at OD 450 nm normalized to a reference serum. Sera from patients that tested positive for AEOSA in the IIF staining were analyzed; E-group refers to sera from AEOSA+/ANCA− patient samples and D-group refers to AEOSA+/ANCA+ patient samples. The cutoff limit (indicated with dashed line) was set at +3 SD above the average signal in serum samples from healthy controls.

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