Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions

Table 2

The clinical characteristics and disease profile of the AEOSA+/ANCA+ individual patients.

	Age (years)	Sex	Anti-TPO	Anti-TG	Anti-MPO	SMA/AMA/Par (IF)	Liver antibodies	AEOSA specificity	Disease history
									GI/Liver disease	Thyroid disease	Other diseases
D1	66	M	Negative		Positive	Negative	Negative	EPX+			Vasculitis (MPA)
D2	57	M	Negative		Positive	Negative	Negative	EPX+			Kidney disease unspecified
D3	48	F	Negative	Negative	Positive	n.a.	Negative	EPX borderline	Liver steatosis	Hyperthyroidism	Fibromyalgia, vitiligo, pulmonary embolism
D4	18	F	Negative		Positive	Negative	Negative	EPX−			Vasculitis (GPA)
D5	69	F	Negative	Negative	Positive		Negative	EPX+			Vasculitis (MPA), breast cancer, pituitary tumor, history of alcohol abuse
D6	71	M	n.a.		Positive	n.a.	n.a.	n.a.
D7	77	F	Negative		Positive	Negative	Negative	EPX+; ECP+; EDN+			Chronic laryngitis, chronic rhinitis, sinusitis, duodenitis, COPD, diabetes type II
D8	70	F	Negative		Positive	Par 640	Negative	n.a.	Atrophic gastritis	Thyrotoxicosis	Nonallergic asthma, primary hyperparathyroidism, polyneuropathy
D9	70	F	Negative		Negative	SMA 80	Negative	EPX+; ECP+	Ulcerative colitis	Hypothyroidism	Lichen planopilaris, diabetes type II, chronic kidney failure
D10	80	M	Borderline	Borderline	Positive	Par 80	LC-1(+); gp210+; 3E(BPO)+	EPX+		Hypothyroidism	MDS, vasculitis (giant cell arthritis)
D11	43	F	Positive		Positive	Negative	SLA/LP+; gp210+; PML+; LC-1(+)	EPX+		Hyperthyroidism	Ehler–Danlos syndrome, asthma
D12	36		Positive		Positive	n.a.	n.a.	EPX+		Hashimoto thyroiditis	Vasculitis (IgA nephritis)
D13	66	F	Positive	Positive	Positive	Par 80	M2+	EPX+; ECP+	Pernicious anemia	Hashimoto thyroiditis	Diabetes mellitus type I, vitiligo, skin vasculitis/urticaria
D14	36	F	Borderline		Positive	Negative	Negative	n.a.			SLE, pericarditis, urticaria
D15	71	F	Positive		Positive	SMA 80	LKM-1(+)	n.a.			Recurrent urticaria, allergic rhinitis/asthma
D16	71	F	Negative	Negative	Negative	Par 640	LC-1(+); LKM-1(+)	n.a.			Pericarditis, palmoplantar psoriasis

Liver antibody profile tested includes AMA, AMA-M2, 3E (BPO), PML, Sp100, gp210, LKM-1, LC-1, and SLA/LP. Abbreviations: TPO, thyroid peroxidase; TG, thyroglobulin, MPO, myeloperoxidase; IF, immunofluorescence; SMA, smooth muscle antibody; AMA, antimitochondrial antibodies; Par, parietal cell antibodies; AEOSA, antieosinophil cytoplasmic antibodies; GI, gastrointestinal; EPX, eosinophil peroxidase; ECP, eosinophil cationic protein; EDN, eosinophil-derived neurotoxin; MPA, microscopic polyangitis; GPA, granulomatosis with polyangiitis; COPD, chronic obstructive pulmonary disease; SLE, systemic lupus erythematosus; n.a., not available.