Antieosinophil Antibodies Alone or in Combination with Antineutrophil Cytoplasmic Antibodies (ANCA) Detected in Different Autoimmune Conditions

Table 3

The clinical characteristics and disease profile of the AEOSA+/ANCA− individual patients.

	Age (years)	Sex	Anti-TPO	Anti-TG	SMA/AMA/Parietal IF	Liver antibodies	AEOSA	Disease history
								GI/Liver disease	Thyroid disease	Other diseases
E1	69	F	Borderline		Negative	Negative	EPX+; ECP+	Ulcerative colitis	Hypothyroidism	AS, pustular psoriasis
E2	75	M	Negative		SMA 80	Negative	EPX+	Pernicious anemia	Hyperthyroidism	AIHA, alcohol abuse
E3	54	F	Positive	Positive	SMA 80	Negative	EPX+			Asthma, obesity
E4	73	F	Negative		Negative	SLA/LP(+); PML(+) 3E(BPO)(+)	EPX+; ECP+; EDN+	Collagenous colitis
E5	54	F	Negative	Negative	n.a.	3E(BPO)(+)	EPX−	Liver fibrosis		HCV
E6	81	M	n.a.		Negative	SLA/LP(+); PML(+); 3E(BPO)(+)	EPX−			Obesity, RA, calcitonin hypersecretion
E7	36	M	Negative		Negative	Negative	EPX−	Liver fibrosis		Kidney Tx (hereditary nephropathy)
E8	64	F	Negative		Negative	3E(BPO)(+)	EPX−			B-cell lymphoma, bilateral uveitis
E9	78	M	Negative	Negative	Negative	Negative	EPX+; ECP+	Suspected liver fibrosis		MDS
E10	35	F	Negative		Negative	PML(+); 3E(BPO)(+)	EPX+; ECP+			AS, MCTD
E11	53	M	Negative		Negative	PML(+); LC-1(+)	EPX+			Alcohol abuse, CHD, obesity, kidney failure
E12	53	F	Negative		Negative	PML(+); 3E(BPO)(+)	EPX+; ECP+	Ulcerative colitis,liver failure episode		AS, fibromyalgia, allergic asthma/rhinitis
E13	54	F	Negative		Negative	Negative	EPX+	Liver Tx		Chronic kidney failure, APS-1
E14	47	F	Negative		Negative	Negative	EPX+			Chronic sinusitis, asthma
E15	62	F	Negative	Negative	Negative	Negative	EPX+			Kidney sclerosis, alcohol abuse, primary parathyroidism
E16	49	M	Negative	Negative	Negative	Negative	EPX−	Ulcerative colitis, PBC—liver Tx
E17	30	M	Negative	Negative	Negative	n.a.	n.a.			Vasculitis (IgA nephritis)
E18	42	F	Negative		Negative	M2(+); gp210++; LKM-1+; LC-1(+); SLA+	n.a.			Fibromyalgia, asthma
E19	23	F	n.a.		n.a.	n.a.	n.a.
E20	70	F	Negative	Negative	Negative	LC-1(+)	n.a.			Emphysema

Liver antibody profile tested includes AMA, AMA-M2, 3E (BPO), PML, Sp100, gp210, LKM-1, LC-1, and SLA/LP. For anti-TG only, known results are indicated. Abbreviations: M, male; F, female; TPO, thyroid peroxidase; TG, thyroglobulin; MPO, myeloperoxidase; IF, immunofluorescence; SMA, smooth muscle antibody; AMA, antimitochondrial antibodies; Par, parietal cell antibodies; AEOSA, antieosinophil cytoplasmic antibodies; GI, gastrointestinall Tx, transplanted; AS, ankylosing spondylitis; AIHA, autoimmune hemolytic anemia; HCV, hepatitis C virus; RA, rheumatoid arthritis; MDS, myelodysplastic syndrome; MCTD, mixed connective tissue disease; CHD, coronary heart disease; APS-1, autoimmune polyendochrine syndrome-1; n.a., not available.