c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4

Figure 3

TBK1 induces endotoxin tolerance by negatively regulating p100 processing: (a) Western blotting analysis of p-TBK1, TBK1, NIK, P-P100, and NF-κB/p100 protein expression. Densitometric analysis of the Western blotting data; (b) the expression of the TNF-α and IL-10 in the culture supernatant of RAW264.7 cells were detected by ELISA. Data are represented as the mean ± SD of at least three independent experiments; one-way ANOVA with Dunnett’s multiple comparisons was used. , , , .

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