Exploration of Lipid Metabolism Alterations in Children with Active Tuberculosis Using UHPLC-MS/MS

Table 2

Details of the differential lipid metabolites between the active TB and the non-TB groups.

Metabolites	Polarity for quantitation	Formula	Molecular weight	RT (min)	TB vs. HC				TB vs. DC
					FC	value	VIP	Trend	FC	value	VIP	Trend
OxPI (18:0-18:1+1O(1Cyc))	Negative	C45 H83 O14 P	878.5533	8.99	10.40	2.20-05	1.67	↑	6.21	4.24-02	1.46	↑
PC (12:0/18:1)	Positive	C38 H74 N O8 P	703.5152	9.46	2.49	1.02-04	1.87	↑	1.65	3.96-02	1.36	↑
PC (16:0/15:1)	Positive	C39 H76 N O8 P	717.5311	10.00	3.97	5.28-07	1.16	↑	1.57	4.14-02	1.32	↑
PE (18:1/20:3)	Positive	C43 H78 N O8 P	767.5468	13.16	3.47	8.40-09	1.33	↑	1.53	9.46-03	1.59	↑
PC (15:0/17:1)	Positive	C40 H78 N O8 P	731.5467	12.57	3.08	1.95-07	1.21	↑	1.55	1.88-02	1.51	↑
PC (17:1/18:2)	Positive	C43 H80 N O8 P	769.5641	12.56	2.44	1.83-06	1.10	↑	1.59	8.24-03	1.70	↑
PE (18:0e/20:4)	Negative	C43 H80 N O7 P	753.5683	13.18	0.47	1.02-05	1.18	↓	0.55	1.05-02	1.45	↓
PE (18:1e/22:5)	Negative	C45 H80 N O7 P	777.5684	13.37	0.55	3.34-06	1.36	↓	0.66	6.21-03	1.84	↓
PC (18:3e/16:2)	Positive	C42 H76 N O7 P	737.5371	9.56	0.09	1.05-08	1.10	↓	0.59	1.27-02	1.64	↓
PC (20:5e/18:2)	Positive	C46 H80 N O7 P	789.5663	9.79	0.53	3.51-04	1.11	↓	0.61	2.18-04	2.72	↓
PC (22:3e/22:6)	Positive	C52 H88 N O7 P	869.6272	12.19	0.57	1.32-05	1.09	↓	0.65	1.85-03	1.88	↓
SM (d14:3/26:2)	Positive	C45 H83 N2 O6 P	778.5984	10.16	0.43	8.17-07	1.43	↓	0.61	2.87-03	2.08	↓

TB: tuberculosis; HC: healthy control; DC: disease control; FC: fold change; VIP: variable importance in the projection.