Broadly Reactive SARS-CoV-2-Specific T-Cell Response and Participation of Memory B and T Cells in Patients with Omicron COVID-19 Infection

Figure 4

Strength and magnitude of SARS-CoV-2-S1 specific IFN-γ producing T-cell response among Omicron-infected patients. PBMCs isolated from all subjects were cultured with gamma-irradiated SARS-CoV-2 whole virus antigen, recombinant S1 protein (wild type), and recombinant S1 protein (delta variant) in vitro. IFN-γ secreting cell frequencies were determined by ELISPOT assay. (a) Strength in terms of SFC per 10⁵ cells and (b) magnitude of the SARS-CoV-2-S1 specific IFN-γ producing T-cell response in terms of percentage. (A) Total Omicron-infected patients (n = 17); (B) vaccinated Omicron-infected patients (n = 14); (C) uninfected Omicron patients (n = 3).

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