Broadly Reactive SARS-CoV-2-Specific T-Cell Response and Participation of Memory B and T Cells in Patients with Omicron COVID-19 Infection

Figure 6

Receiver operating characteristic (ROC) for IL-6, IFN-γ, IL-8, CCL-2, CCL-3, CCL-4, CCL-5, and IL-8. ROC curves for IL-1β, TNF-α, CXCL-10, and IL-4, validating their applicability as biomarkers of recent infection. The ROC characteristics of (a) IL-6: cutoff: 0.33 pg/mL, sensitivity: 95%, specificity: 91.67%, AUC = 0.9056; (b) IFN-γ: cutoff: 3.48 pg/mL, sensitivity: 100%, specificity: 86.11%, 0.9583; (c) IL-8: cutoff: 2.61 pg/mL, sensitivity, 100%: specificity: 97.22%, AUC = 0.9722; (d) CCL-2: cutoff: 13.78 pg/mL, sensitivity: 100%, specificity: 97.22%, AUC = 0.9750, (e) CCL-3: cutoff: 0.25 pg/mL, sensitivity: 100%, specificity: 88.89%, AUC = 0.9569; (f) CCL-4: cutoff: 69.53 pg/mL, sensitivity: 100%, specificity: 97.22%, AUC = 0.9722; (g) CCL-5: cutoff: 4547.35 pg/mL, sensitivity: 100%, specificity: 91.67%, AUC = 0.9722. The area under the curve (AUC) values of the above analytes were greater than 0.9 (), which is indicative of higher diagnostic value. The high sensitivity and specificity of the analytes’ cutoffs suggest that they can potentially act as biomarkers of Omicron infection.

(a)

(b)

(c)

(d)

(e)

(f)

(g)