Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p

<div>iMSC-sEV ameliorated AMs inflammatory response and inhibited the NF-<i>κ</i>B signaling pathway activation induced by LPS in vitro. (a) Pro-inflammatory cytokines IL-1<i>β</i>, TNF-<i>α</i>, and IL-6 levels in the supernatant of AMs treated with iMSC-sEV. (b) Representative western blot and quantitative analysis of p-p65 and p65 in recipient AMs treated with iMSC-sEV. (c) Detection of the uptake effects of AMs on PKH-67-labelled iMSC-sEV by means of fluorescent microscopy. 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Journal of Immunology Research

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Figure 3

Figure 3: Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p 

Figure 3 | Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p 