Research Article

lncRNA HCG11 Promotes Colorectal Cancer Cell Malignant Behaviors via Sponging miR-26b-5p

Figure 5

HCG11 exacerbates CRC cell malignant behaviors through modulating the miR-26b-5p/ARPP19 axis. (a) The overexpression efficiency of pcDNA3.1-ARPP19 was assessed through qRT-PCR. HCT15 and HT-29 cells transfected with sh-NC, sh-HCG11#1, sh-HCG11#1+miR-26b-5p, or sh-HCG11#1+pcDNA3.1-ARPP19 were used for functional assays in a rescue manner. (b, c) CRC cell proliferation was evaluated by EdU assay and colony formation assay. (d, e) The cell apoptosis ability was measured via TUNEL assay and JC-1 assay. (f, g) The cell migration and invasion abilities were detected via transwell assay. .
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