Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases

Table 1

Demographic characteristics and disease distribution of the included patients.

Parameters	Groups				values			Overall
	All:	Group A: Ro52 alone ()	Group B: Ro60 alone ()	Group C: Ro60 and Ro52 ()	Group A vs. group B	Group A vs. group C	Group B vs. group C
Female (, %)	1362 (85.3)	217 (72.1)	263 (84.8)	882 (89.5)	<0.0001	<0.0001	0.024	<0.0001
Age, years ()					<0.0001	<0.0001	0.975	<0.0001
AIDs (, %)	1340 (84.0)	176 (58.5)	286 (92.3)	878 (89.1)	<0.0001	<0.0001	0.112	<0.0001
SLE	617 (46.0)	31 (17.6)	136 (47.6)	450 (51.3)	<0.0001	<0.0001	0.277	<0.0001
SS	254 (19.0)	27 (15.3)	37 (12.9)	190 (21.6)	0.468	0.059	<0.0001	0.002
RA	106 (7.90)	26 (14.8)	33 (11.5)	47 (5.4)	0.312	<0.0001	0.008	<0.0001
UCTD	195 (14.6)	31 (17.6)	45 (15.7)	119 (13.6)	0.597	0.159	0.357	0.308
IM	58 (4.3)	33 (18.8)	3 (1.0)	22 (2.5)	<0.0001	<0.0001	0.140	<0.0001
SV	12 (0.9)	2 (1.1)	7 (2.4)	3 (0.3)	0.322	0.161	0.001	0.004
SSc	30 (2.2)	8 (4.5)	11 (3.8)	11 (1.3)	0.713	0.003	0.005	0.003
APS	3 (0.2)	0 (0)	2 (0.7)	1 (0.1)	NA	NA	0.090	0.152
MCTD	4 (0.3)	1 (0.6)	1 (0.3)	2 (0.2)	0.728	0.439	0.724	0.740
Overlap syndrome	19 (1.4)	4 (2.3)	3 (1)	12 (1.4)	0.296	0.370	0.679	0.545
SpA	9 (0.7)	3 (1.7)	4 (1.4)	2 (0.2)	0.794	0.009	0.016	0.022
Organ-specific AIDs	21 (1.6)	7 (4.0)	3 (1.0)	11 (1.3)	0.036	0.011	0.784	0.021
RP	1 (0.1)	0 (0)	1 (0.3)	0 (0)	NA	NA	NA	NA
AOSD	2 (0.1)	0 (0)	0 (0)	2 (0.2)	NA	NA	NA	NA
ITP	9 (0.7)	3 (1.7)	0 (0)	6 (0.7)	NA	0.371	NA	0.054
Non-AIDs (, %)	256 (16.0)	125 (41.5)	24 (7.7)	107 (10.9)	<0.0001	<0.0001	0.095	<0.0001
Malignancies^$	63 (24.6)	38 (30.4)	2 (8.3)	23 (21.5)	0.025	0.125	0.138	0.044
Chronic diseases	66( 25.8)	38 (30.4)	2 (8.3)	26 (24.3)	0.025	0.300	0.085	0.069
Infections	50 (19.5)	24 (19.2)	5 (20.8)	21 (19.6)	0.853	0.935	0.893	0.983
Osteoarthritis	22 (8.6)	8 (6.4)	11 (45.8)	3 (2.8)	<0.0001	0.199	<0.0001	<0.0001
Gout	7 (2.7)	3 (2.4)	2 (8.3)	2 (1.9)	0.139	0.781	0.096	0.204
Gestation^#	8 (3.1)	4 (3.2)	0 (0)	4 (3.7)	NA	0.823	NA	0.635
Others^†	40 (15.6)	10 (8.0)	2 (8.3)	28 (26.2)	0.956	<0.0001	<0.0001	<0.0001

^$Malignancies include lung cancer (), lymphoma (), as well as colorectal (), gastric (), breast (), ovarian (), prostate (), and nasopharyngeal () cancers. Chronic diseases include chronic obstructive pulmonary diseases, chronic kidney disease, chronic heart failure, sequelae of cerebral infarction, hypertension, and diabetes mellitus. ^#Gestation includes preeclampsia, eclampsia, recurrent spontaneous abortion, and gestational hypertension. ^†Others include acute myocardial infarction, acute cerebral hemorrhage, anemia, arrhythmia, etc. AIDs: autoimmune diseases; SLE: systemic lupus erythematosus; SS: primary Sjögren’s syndrome; RA: rheumatoid arthritis; UCTD: undifferentiated connective tissue disease; IM: inflammatory myositis; SV: systemic vasculitis; SSc: systemic sclerosis; APS: antiphospholipid syndrome; SpA: spondylarthritis; MCTD: mixed connective tissue disease; RP: relapsing polychondritis; AOSD: adult-onset Still’s disease; ITP: immune thrombocytopenic purpura; NA: not applicable.