House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Figure 1

Sensitization and challenge protocols. Experimental models of acute (4 weeks), subacute (8 weeks), and chronic (12 weeks) HDM- or CDE-induced allergic airway inflammation in guinea pigs. The protocol for allergen exposure involved a sensitization phase (black dots) followed by a challenge phase (open dots).