House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Figure 2

Guinea pigs exhibit a marked inflammatory reaction and remodelling to clinically relevant allergens, HDM and CDE. (a) Representative histological sections of H&E-stained lungs. (b) Analysis of infiltration of inflammatory cells infiltrated into the airway subepithelial region and (c) airway smooth muscle thickness. All measured areas (μm²) were adjusted by the basement membrane (BM) perimeter (μm). Data are the of -5 animals per group. Scale bars correspond to 100 μm. , , , and . ASML: airway smooth muscle layer; BM: basement membrane; HDM: house dust mite extract; CDE: cat dander extract.

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