Research Article

House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model

Figure 3

Guinea pigs exposed to HDM and CDE elicit hallmark features for airway remodelling. (a) Representative histological sections of Picro-Sirius Red-stained lungs and (b) analysis of collagen accumulation within the airway subepithelial region. Collagen-positive areas (μm2) were adjusted by the BM perimeter (μm). Data are of -5 animals per group. Scale bars correspond to 100 μm. , , and . BM: basement membrane; HDM: house dust mite extract; CDE: cat dander extract.
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