Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis

Figure 2

Landscape of immune cell infiltration in RA synovium and aberrant B-cell-related signaling pathways. (a) Heatmap of 28 immune cell infiltration in the synovium of ACPA-positive (+)/-negative (−) RA, early/established RA patients, OA patients, and healthy controls (normal). (b) Boxplot of 28 immune cell infiltration among ACPA-positive (+)/-negative (−) RA, early/established RA patients, OA patients, and healthy controls (normal). (c) Representative images of immunohistochemical staining of CD20 between RA (n = 6) and OA synovium (n = 6). (d and e) GSEA analysis of 51 B-cell-related biological pathways between RA patients and HC, RA patients, and OA patients. , , , ns = not significant.

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