Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis

Figure 3

Screening of B-cell-related differential expression genes. (a) UpSet plot of overlap of differential expression genes detected across comparisons among RA patients and HC, RA patients, OA patients, and B-cell-related genes. (b) Heatmap of 55 B-cell-related differential expression genes in RA synovium. (c) Protein–protein interaction network of 55 B-cell-related differential expression genes. (d) The highly interconnected subclusters identified by the Cytoscape plug-in MCODE. (e) GO enrichment analyses of 55 B-cell-related differential expression genes. (f) KEGG enrichment analyses of 55 B-cell-related differential expression genes.

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