Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies

Figure 1

Increased frequency of intermediate monocytes in AAV patients compared to healthy controls. The frequencies of (a) classical (CD14⁺⁺CD16⁻), (b) intermediate (CD14⁺⁺CD16⁺), (c) nonclassical (CD14⁻CD16⁺) monocytes, and (d) neutrophils CD177⁺ in AAV patients and HC, analyzed with flow cytometry, as described in Section 2. AAV patients present a higher frequency of intermediate monocytes and neutrophils CD177⁺, but not of classical and nonclassical, compared to HC. Mann–Whitney U test was used to calculate the level of significance. Data are presented with medians. Indicates p-value < 0.0001. WBC, white blood cell; AAV, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis; HC, healthy controls; ns, not significant.

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