Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies

Figure 4

Comparison of granulocyte and monocyte frequencies in patients with and without a tendency to relapse (Ttr). Frequencies of (a) eosinophils, (b) mature CD16^high, and (c) CD177⁺ neutrophils in AAV patients with Ttr or No Ttr, where patients with Ttr presented decreased frequency of eosinophils, but increased frequency of mature neutrophils and CD177⁺ neutrophils. Analysis of cell subsets in GPA patients with Ttr and without Ttr demonstrated statistically significant increased frequencies of (d) mature CD16^high and (e) CD177⁺ neutrophils. The investigation of the cell subsets in MPA patients with Ttr and without Ttr identified decreased frequency of (g) intermediate (CD14⁺⁺CD16⁺) monocytes but no statistically significant difference of (f) classical (CD14⁺⁺CD16⁻), and (h) nonclassical (CD14⁻CD16⁺) monocytes. Mann–Whitney U test was used to calculate the level of significance. Data are presented with medians. and Indicate p-value < 0.05 and <0.01, respectively. AAV, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis; Ttr, tendency to relapse; No Ttr, no tendency to relapse; GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis; ns, not significant.

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