| | AAV (n = 105) | GPA (n = 68) | MPA (n = 37) |
| | Age, (year), median (IQR) | 69 (56–77) | 65.5 (48–74) | 73 (63–80) | | Gender, female/male, n (%) | 50 (48)/55 (52) | 30 (44)/38 (56) | 20 (54)/17 (46) | | Age at diagnosis, years, median (IQR) | 59 (39–70) | 52 (34–66) | 68 (54–74) | | ANCA specificity, n (%) | | | | | PR3 | 60 (57) | 54 (79) | 6 (16) | | MPO | 40 (38) | 12 (18) | 28 (76) | | PR3 and MPO | 1 (1) | 0 (0) | 1 (3) | | No ANCA | 3 (3) | 2 (3) | 1 (3) | | Data not available | 1 (1) | 0 (0) | 1 (3) | | Disease activity | | | | | Active disease, n (%) | 14 (13) | 8 (12) | 6 (16) | | BVAS3, median (IQR) | 5 (3–13) | 3 (2–6) | 14 (5–15) | | Remission, n (%) | 91 (87) | 60 (88) | 31 (84) | | Tendency to relapse, n (%) | | | | | Yes | 47 (45) | 37 (54) | 10 (27) | | No | 34 (32) | 19 (28) | 15 (41) | | Not applicable | 24 (23) | 12 (18) | 12 (32) | | WBC, ×109/L, median (IQR) | 6.5 (5.2–8.1) | 6.0 (5.1–7.9) | 6.8 (5.5–8.8) | | P-CRP, (mg/L), median (IQR) | 2.3 (1.2–5.6) | 2.0 (1.1–4.0) | 4.7 (1.4–8.5) | | S-creatinine, (μmol/L), median (IQR) | 110 (82–154) | 98 (78–144) | 133 (97–180) | | eGFR, (mL/min/1.73 m2), median (IQR) | 51 (37–74) | 60 (40–84) | 39 (27–56) | | Medication, n (%), dose, median (IQR) | | | | | Rituximab | 22 (21) | 18 (26) | 4 (11) | | Prednisolone, | 60 (57) | 36 (53) | 24 (65) | | mg/day | 5 (5–10) | 5 (5–7.5) | 10 (5–14) | | Azathioprine, | 30 (29) | 18 (26) | 12 (32) | | mg/day | 100 (69–100) | 100 (69–150) | 75 (56–100) | | Methotrexate, | 6 (9) | 6 (9) | 0 (0) | | mg/week | 23 (20–25) | 23 (20–25) | | | Mycophenolate mofetil, | 7 (7) | 5 (7) | 2 (5) | | mg/day | 1.5 (1.5–2) | 2 (1–2) | 1.5 (1.5) | | Cyclophosphamide | 8 (8) | 3 (4) | 5 (14) | | No medication | 26 (25) | 18 (26) | 8 (22) |
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AAV, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis; GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis; IQR, interquartile range; ANCA, antineutrophil cytoplasmatic antibody; PR3, proteinase 3; MPO, myeloperoxidase; BVAS3, Birmingham vasculitis activity score version 3; WBC, white blood cell; CRP, C-reactive protein. eGFR (estimated glomerular filtration rate) was calculated by the CKD-EPI Creatinine (2009) equation ( http://www.mdrd.com). Reference range adults: WBC 3.5–8.8 × 10 9/L, CRP < 5.0 mg/L, creatinine 60–105 µmol/L (male), 45–90 µmol/L (female). |
