Association between Variation of Troponin and Prognosis of Acute Myocardial Infarction before and after Primary Percutaneous Coronary Intervention

Table 1

Baseline characteristics of the study cohort.

	All enrolled	cTnI pre-PPCI cohort	Cohort of the maximum troponin in measurement data	△cTnI cohort
N	3586	1927	1809	1138
Age (years)	59 (16)	58 (18)	57 (19)	59(12.31)
Male (%(n))	75.7 (2713)	73.3 (1412)	72.2 (1306)	68.5 (779)
Time from the onset of symptoms to admission (h)	7.00 (8.00)	7.00 (9.00)	7.00 (8.00)	7.00 (9.00)
Time from the onset of symptoms to balloon (h)	15.97 (18.43)	15.58 (23.90)	14.86 (25.58)	14.38 (20.46)
BMI (kg/m^2)	25.76 (4.48)	25.26 (5.10)	25.16 (5.46)	25.99 (3.76)
Heart rate (beats per minute)	76 (19)	75 (18)	75 (18)	77 (36)
Systolic blood pressure (mmHg)	122 (25)	123 (24)	123 (24)	124 (40)
Diastolic blood pressure (mmHg)	74 (16)	75 (17)	75(16.5)	77 (25)
History of PCI (%(n))	11.6 (417)	11.4 (220)	10.4 (189)	9.8 (111)
History of CABG (%(n))	0.8 (30)	0.9 (17)	0.8 (15)	0.9 (10)
Risk factors
Hypertension (%(n))	59.6 (2136)	59.1 (1138)	60.1 (1088)	59.3 (675)
Hyperlipidemia (%(n))	77.6 (2782)	71.6 (1380)	71 (1285)	64.9 (739)
Smoking (%(n))	53.1 (1903)	46.7 (900)	45.8 (828)	38.5 (438)
Diabetes (%(n))	32.5 (1165)	33.1 (638)	31.9 (577)	32.2 (366)
Laboratory examinations
cTnI (ng/ml)	—	0.37 (3.00)	4.16 (14.73)	3.71 (15.78)
Total cholesterol (mg/dl)	2.40 (3.31)	2.97 (3.09)	3.07 (3.33)	1.37 (1.04)
HDL-cholesterol (mg/dl)	1.12 (3.94)	1.87 (3.35)	1.26 (3.22)	3.15 (1.82)
LDL-cholesterol (mg/dl)	2.30 (3.06)	2.42 (1.8)	2.60 (1.34)	1.43 (1.28)
Triglycerides (mg/dl)	1.02 (3.31)	1.04 (0.98)	1.05 (1.03)	0.96 (0.58)
ALT (IU/L)	23.00 (41.00)	28.00 (41.10)	33.00 (42.93)	25.44 (5.62)
AST (IU/L)	43.00 (74.00)	55.00 (78.00)	55.00 (25.00)	26.00 (41.00)
TBil (ummol/L)	11.00 (23.00)	14.00 (24.00)	15.00 (4.90)	29.00 (60.00)
D-BIL (ummol/L)	1.50 (3.70)	2.27 (5.10)	2.60 (4.90)	13.00 (21.58)
ApoA (g/L)	1.21 (3.52)	1.25(3.23)	1.37 (4.09)	7.43 (88.34)
ApoB (g/L)	1.08 (0.38)	1.05(0.35)	1.04(0.38)	1.40(4.49)
Echocardiography data before PPCI
LAD (mm)	35.00 (5.00)	35 (5.00)	35.00 (5.00)	35.00 (5.00)
IVSd (mm)	10.00 (1.00)	10.00 (8.00)	10 (1.00)	7.00 (8.00)
LVEDV (mm)	49 (6.00)	49.00 (6.00)	49.00 (6.00)	49.00 (6.00)
LVPWs (mm)	9.00 (1.00)	9.00 (1.00)	9.00 (1.00)	9.00 (1.00)
EF (%)	55.00 (10.00)	56 (0.00)	55.00 (42.92)	56.00 (10.00)
Discharge medication regimen
Statin (%(n))	81.5 (2921)	76.0 (1465)	72.2 (1307)	65.6 (747)
Aspirin (%(n))	64.7 (2321)	76.8 (1479)	61.2 (1107)	67.0 (762)
Clopidogrel (%(n))	66 (2367)	52.3 (1007)	54.9 (993)	42.9 (488)
Ticagrelor (%(n))	20.1 (721)	27.9 (537)	21.9 (397)	27.0 (307)
Warfarin (%(n))	0.4 (15)	0.3 (6)	0.4 (8)	0.2 (2)
ACEI (%(n))	56.1 (2011)	54.0 (1040)	51.6 (933)	47.6 (542)
ARB (%(n))	6.7 (242)	6.3 (122)	6.7 (122)	5.9 (67)
Beta-blockers (%(n))	76 (2726)	71.1 (1370)	67.6 (1222)	62.0 (706)
Ezetimibe (%(n))	0.7 (26)	1.1 (21)	0.9 (17)	1.2 (14)
Diuretic (%(n))	26 (931)	21.9 (422)	22.6 (409)	18.6 (212)
Endpoint events
MACE (%(n))	8.2 (293)	4.9 (94)	5.9 (107)	4.1 (47)
Death (%(n))	6 (215)	3.1 (59)	3.9 (70)	2.3 (26)
CV death (%(n))	4.8 (170)	1.9 (37)	2.9 (53)	1.2 (13)
Stroke (%(n))	1.9 (68)	1.3 (26)	1.7 (31)	1.5 (17)

Continuous data are presented as mean ± SD; categorical variables are presented as % (n). cTnI, cardiac troponin I; PPCI, primary percutaneous coronary intervention; BMI, body mass index; PCI, primary percutaneous coronary intervention; CABG, coronary artery bypass grafting; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; D-BIL, direct bilirubin; ApoA, apolipoprotein A; ApoB, apolipoprotein B; LAD, left atrial diameter; IVSd, interventricular septal thickness diameter; LVEDV, left ventricular end systolic volume; LVPWs, left ventricular posterior wall thickness; EF, ejection fraction; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; MACE, major adverse cardiovascular events; CV death, cardiovascular death.