|
| Study | Patients (lesions) | Diabetes mellitus (%) | Previous myocardial infarction | Lesion length (mm) | Diameter stenosis (%) | Prevalence of ischaemia (FFR≤0.80) | Mean/median FFR | Correlation | AUC | Exclusion criteria |
|
| VFR |
| Morris et al. [11] | 19 (19) | 5 | 5% | NA | NA | NA | NA | 0.84 | 0.97 | Previous MI |
| Significant LMS stenosis |
| Previous CABG or PCI |
| Too obese for rotational coronary angiography |
| Morris et al. [13] | 20 (73) | 30 | 45% | NA | NA | NA | NA | 0.77 | 1 | Previous CABG |
| Chronic total occlusion |
| Acute presentation within the last 60 days |
| Gosling et al. [14] | 54 (59) | 22 | 43% | NA | NA | NA | 0.66 ± 0.14 | 0.87 | 0.93 | Previous CABG |
| Chronic total occlusion |
| Acute presentation within the last 60 days |
|
| vFAI |
| Papafaklis et al. [15] | 120 (139) | 28 | 31% | 59.4 ± 21.0 | 61.4 ± 13.1 | 37% | 0.84 (IQR 0.75–0.90) | 0.78 | 0.92 (0.86–0.96) | Significant LMS disease |
| Bifurcation lesions |
| Infarct-related vessels |
| Vessels with ostial stenosis |
| Previous CABG |
|
| QFR |
| Tu et al. [16] | 77 (68) | 29 | 22% | NA | 46.6 ± 7.3 | 30% | 0.82 ± 0.10 | 0.81 | 0.93 (0.86–0.99) | Interrogated vessel with significant overlap or foreshortening (>90%) |
| Hyperaemic image quality insufficient for frame counting |
| Mean pressure in the guiding catheter or blood haematocrit are unavailable |
| Tu et al. [17] | 73 (84) | 27 | 32% | NA | 46.1 ± 8.9 | 32% | 0.84 ± 0.08 | 0.77 | 0.92 (0.85–0.97) | Ostial LMS or RCA lesion |
| Prior CABG |
| Xu et al. [19] | 304 (328) | 28 | 16% | 13.1 ± 6.4 | 46.5 ± 11.3 | 34% | 0.82 ± 0.12 | 0.86 | 0.96 (0.94–0.98) | Ostial lesions <3 mm from aorta |
| Severe vessel overlap or tortuosity |
| Luminal reduction due to myocardial bridge |
| Poor angiographic image quality |
| Main vessels with stenotic side branches downstream of interrogated lesion |
| Westra et al. [24] | 172 (255) | 10 | NA | NA | 50 ± 12 | 36% | 0.82 ± 0.11 | 0.70 | 0.86 (0.81–0.91) | Ostial LMS or RCA stenosis |
| <2 projections of visible stenosis |
| No nitroglycerin administration |
| Pressure wire position not documented |
| Westra et al. [18] | 272 (317) | 29 | NA | 9.64 (IQR 7.53–13.76) | 45 ± 10 | 33% | 0.83 ± 0.09 | 0.83 | 0.92 (0.89–0.96) | Medina type 1,1,1 and 1,0,1 lesions |
| Aorto-ostial lesions |
| Poor angiographic quality |
| No nitroglycerin administration |
| Stenosis at or near large diameter shifts (>1 mm) |
| Severe tortuosity or overlap |
|
| FFRangio |
| Pellicano et al. [20] | 184 (203) | 32 | 19% | NA | NA | NA | 0.81 ± 0.11 | 0.81 | 0.93 | Ostial LMS or RCA stenosis |
| LMS stenosis |
| In-stent restenosis of the target vessel |
| Previous CABG |
| Diffuse coronary artery disease |
| Fearon et al. [25] | 301 (319) | 32 | NA | NA | 51 ± 10 | 43% | 0.81 ± 0.13 | 0.80 | 0.94 (0.92–0.97) | LMS stenosis >50% |
| Recent (<12 months) stent placement in the target vessel |
| In-stent restenosis |
| Severe diffuse disease |
| Target vessel supplied by collaterals |
| Inadequate angiographic image quality |
|
| FFRsim |
| Tar et al. [21] | 64 (68) | 27 | 52% | NA | 46 | NA | NA | 0.86 | 0.96 (0.91–1) | Previous CABG |
| Bifurcation lesions |
| Ostial LMS stenosis |
|
| vFFR |
| Masdjedi et al. [22] | 100 (100) | 26 | NA | 20 ± 13 | 37 ± 13 | 42% | 0.82 ± 0.08 | 0.89 | 0.93 (0.88–0.97) | LMS stenosis |
| Previous CABG with collaterals |
| Cardiogenic shock or severe haemodynamic instability |
| STEMI or lesions containing thrombus |
|
