Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes

Figure 5

ROC curve documenting the ability of diurnal/nocturnal PVC burden ratio to differentiate LVOT and ASV origins. ROC curves plotting the true-positive rate (sensitivity) versus false-positive rate (1 − specificity) documenting the ability of diurnal/nocturnal burden ratio to differentiate LVOT and ASV origins in all patients (blue curve, AUC = 0.827) and in patients without PVC recurrence after ablation (red curve, AUC = 0.910). The ROC curve in combination with Youden’s index supports a diurnal/nocturnal burden ratio of 0.92 as a cutoff. ASV, aortic sinus of Valsalva; AUC, area under the curve; LVOT, left ventricular outflow tract; PVC, premature ventricular complexes; ROC, receiver-operating characteristic.