Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry

Table 1

Baseline characteristics according to SB treatment.

	Total (n = 1,089)	SB treatment (n = 548)	No SB treatment (n = 541)	value
Patient factors
Sex (male, %)	762 (70.0)	396 (72.3)	366 (67.7)	0.11
Age (years)	64.7 ± 10.9	63.9 ± 11.1	65.5 ± 10.6	0.01
BMI (kg/m^2)	24.4 ± 3.1	24.4 ± 3.1	24.4 ± 3.1	0.88
Current smoker	301 (27.6)	157 (28.7)	144 (26.6)	0.50
Comorbidities
Hypertension	669 (61.4)	318 (58.0)	351 (64.9)	0.02
Diabetes	391 (35.9)	173 (31.6)	218 (40.3)	<0.01
Dyslipidemia	668 (61.3)	333 (60.8)	335 (61.9)	0.74
CKD	48 (4.4)	17 (3.1)	31 (5.7)	0.04
CVA	91 (8.4)	46 (8.4)	45 (8.3)	1.00
PAD	15 (1.4)	8 (1.5)	7 (1.3)	1.00
FHx of CHD	86 (7.9)	47 (8.6)	39 (7.2)	0.47
Previous MI	48 (4.4)	24 (4.4)	24 (4.4)	1.00
Present with MI	306 (28.1)	162 (29.6)	144 (26.6)	0.31
ACS	647 (59.4)	320 (58.4)	327 (60.4)	0.53
LV dysfunction (EF<40%)	61 (6.6)	23 (4.8)	38 (8.6)	0.03
Serum Cr, mg/dL	0.9 (0.8–1.1)	0.9 (0.8–1.1)	0.9 (0.8–1.2)	0.07
History of PCI or CABG	109 (10.0)	52 (9.5)	57 (10.5)	0.64
Lesion characteristics
3VD	333 (30.6)	139 (25.4)	194 (35.9)	<0.01
2VD	392 (36.0)	187 (34.1)	205 (37.9)
1VD	364 (33.4)	222 (40.5)	142 (26.2)
Medina class				0.96
1, 1, 1	798 (73.3)	401 (73.2)	397 (73.4)
1, 0, 1	89 (8.2)	46 (8.4)	43 (8.0)
0, 1, 1	202 (18.5)	101 (18.4)	101 (18.7)
Calcified lesion	161 (14.8)	57 (10.4)	104 (19.2)	<0.01
Tortuous lesion	226 (20.8)	90 (16.4)	136 (25.1)	<0.01
Procedure characteristics
SB balloon angioplasty	373 (34.3)	373 (68.1)	0 (0)
SB stenting	175 (16.1)	175 (31.9)	0 (0)
IVUS-guidance	471 (43.3)	250 (45.6)	221 (40.9)	0.03
GP IIb-IIIa inhibitor	48 (4.4)	23 (4.2)	25 (4.6)	0.13
Medications
DAPT >1 year	575 (52.8)	281 (51.3)	294 (54.3)	0.34
RAS inhibitor	710 (65.2)	356 (65.0)	354 (65.4)	0.92
Beta-blocker	710 (65.2)	361 (65.9)	349 (64.5)	0.68
ACEF score	1.21 ± 0.48	1.15 ± 0.40	1.27 ± 0.54	<0.01

Values are mean ± SD, median (interquartile ranges, 25^th–75^th), or n (%) (per-patient analysis). Calculated in 904 patients with available values for creatinine and ejection fraction. SB, side-branch; BMI, body mass index; CVA, cerebrovascular accident; PAD, peripheral artery disease; FHx, family history; CHD, coronary heart disease; MI, myocardial infarction; ACS, acute coronary syndrome; LV, left ventricle; EF, ejection fraction; Cr, creatinine; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft surgery; 3VD, three-vessel disease; IVUS, intravascular ultrasound; GP, glycoprotein; DAPT, dual antiplatelet therapy; RAS, renin-angiotensin system; ACEF, age, creatinine, and ejection fraction.