Research Article

Ticagrelor versus Clopidogrel in Patients with Severe Renal Insufficiency Undergoing PCI for Acute Coronary Syndrome

Table 1

Baseline characteristics of the study participants.

VariablesTotal (n = 276)Ticagrelor (n = 108)Clopidogrel (n = 168) value

Male, no.(%)192 (69.6)79 (73.1)113 (67.4)0.473

Age(years),mean ± SD67.5 ± 11.666.3 ± 10.868.2 ± 12.10.24

Diagnosis at discharge, n (%)0.085
 STEMI117 (42.4)48 (44.4)69 (41.1)
 NSTEMI86 (31.2)40 (37.0)46 (27.4)
 Unstable angina73 (26.4)20(18.5)53 (31.5)

Risk factors, n (%)
 Hypertension210 (76.1)78 (72.2)132 (78.6)0.367
 Diabetes109 (39.5)36 (33.3)73 (43.5)0.187
 Current smoker70 (25.4)32 (29.6)38 (22.6)0.326

Previous medical history, n (%)
 Myocardial infarction28 (10.1)12(11.1)16 (9.5)0.798
 Congestive heart failure63 (22.8)20 (18.5)43 (25.6)0.289
 COPD20 (6.9)5 (4.6)15 (8.9)0.204
 Nonhemorrhagic stroke22 (10.2)14 (12.9)16 (9.5)0.466

Dialysis, n (%)50 (18.1)18 (16.7)32 (19.0)0.83

SBP (mmHg), mean ± SD134.8 ± 31.5132.9 ± 30.9135.9 ± 31.90.494

DBP (mmHg), mean ± SD79.5 ± 16.478.6 ± 16.180.0 ± 16.50.57

HR (bpm), mean ± SD86.3 ± 14.687.1 ± 13.485.9 ± 15.30.566

Hemoglobin (g/L), mean ± SD106.2 ± 14.4108.3 ± 10.4105.0 ± 16.10.104

eGFR (ml/min·1.73 m2), median (IQR)17.3 (10.6, 24.3)18.0 (12.3, 24.4)17.0 (9.1, 24.2)0.281

Creatinine (μmol/L), mean ± SD404.2 ± 267.4369.0 ± 227.9424.1 ± 286.30.147

Hs-cTn T (pg/mL), Mean ± SD1544.5 ± 2497.31263.4 ± 2095.71703.3 ± 2692.30.214

CK-MB (U/L), Mean ± SD137.5 ± 192.2130.4 ± 180.0141.4 ± 199.40.688

NT-proBNP(pg/mL), mean ± SD16372.1 ± 11914.714931.3 ± 11720.817186.5 ± 11988.40.182

EF (%), mean ± SD50.4 ± 6.850.5 ± 7.050.4 ± 6.80.936

BMI (kg/m2), mean ± SD23.8 ± 2.224.1 ± 2.223.7 ± 2.10.155

Cholesterol (mmol/L),mean ± SD4.3 ± 1.14.4 ± 1.34.2 ± 1.00.217

LDL-C (mmol/L), mean ± SD2.4 ± 1.02.5 ± 1.12.3 ± 0.90.248

Glucose (mmol/L), mean ± SD8.2 ± 3.38.3 ± 3.28.1 ± 3.30.808

Radial access, n (%)265 (96.0)104 (96.3)161 (95.8)0.714

Number of diseased vessels, n (%)0.144
 One43 (15.6)19 (17.6)24 (14.3)
 Two115 (41.6)36 (33.3)79 (47.0)
 Three118 (42.8)53 (49.1)65 (38.7)

Complete revascularization, n (%)182 (66.0)78 (72.2)102 (62.0)0.387

Medication on arrival, n (%)
 Aspirin276 (100.0)108 (100)168 (100)1
 GP IIb/IIIa inhibitors55 (19.9)28 (25.9)27 (16.1)0.121
 LMWH131 (47.5)47 (43.5)84 (50.0)0.445
 PPI215 (77.9)87 (80.6)128 (76.1)0.532
β-blocker232 (84.1)95 (88.0)137 (81.5)0.28
 ACE inhibitor and/or ARB142 (51.4)56 (51.9)86 (51.2)0.987
 Stain, n (%)276 (100.0)108 (100)168 (100)1
 CCB, n (%)152 (55.1)58 (53.7)94 (56.0)0.752

STEMI, ST-elevation myocardial infarction; NSTEMI, non-ST-elevation myocardial infarction; COPD, chronic obstructive pulmonary disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; eGFR, estimated glomerular filtration rate calculated by the chronic kidney disease epidemiology equation; hs-cTn T, high sensitivity cardiac troponin T; CK-MB, heart-type isoenzyme of creatine kinase; NT-proBNP, N-terminal pro-brain natriuretic peptide; EF, ejection fraction; LDL-C, low-density lipoprotein cholesterol; LMWH, low-molecular-weight heparin; PPI, proton pump inhibitors; CCB, calcium channel blockers.