2005–2007 2008–2010 2011–2013 2014–2016 2017–2019 Linear χ 2 valueWomen AF patients, n 254 536 949 1880 3094 Age, median (IQR) 62 (55–67) 63 (56–69) 63 (57–69) 64 (58–70) 65 (59–71) — <0.001 Age ≥ 75, n (%) 8 (3.1) 35 (6.5) 77 (8.1) 239 (12.7) 420 (13.6) 52.2 <0.001 Age 65–74, n (%) 90 (35.4) 207 (38.6) 334 (35.2) 676(36.0) 1254 (40.5) 6.9 0.009 Time in hospital (d; median, IQR) 11 (8–13) 9 (7–11) 6 (4–8) 5 (3–6) 4 (3–5) — <0.001 Hospital deaths, n (%) — — — — 2 (0.06%) — 0.230 Comorbidity, n (%) Heart failure 6 (2.4) 7 (1.3) 9 (0.9) 44 (2.3) 176 (5.7) 52.1 <0.001 Hypertension 121 (47.6) 301 (56.2) 540 (56.9) 1077 (57.3) 1860 (60.1) 14.8 <0.001 Diabetes mellitus 32 (12.6) 83 (15.5) 164 (17.3) 267 (14.2) 533 (17.2) 2.8 0.09 Stroke/TIA/TE 7 (2.8) 32 (6.0) 55 (5.8) 85 (4.5) 236 (7.6) 12.0 0.001 Vascular disease 20 (7.9) 41 (7.6) 80 (8.4) 232 (12.3) 464 (15.0) 44.7 <0.001 CHA2 DS2 -VA score (mean ± SD) 1.17 ± 1.06 1.43 ± 1.19 1.46 ± 1.26 1.56 ± 1.31 1.81 ± 1.39 — <0.001 Score 0, n (%) 78 (30.7) 128 (23.9) 246 (25.9) 479 (25.5) 629 (20.3) 21.3 <0.001 Score 1 n (%) 91 (35.8) 177 (33.0) 286 (30.2) 506 (26.9) 751 (24.3) 36.3 <0.001 Score ≥ 2 n (%) 85 (33.5) 231 (43.1) 417 (43.9) 895 (47.6) 1714 (55.4) 85.5 <0.001 CHADS2 score (mean ± SD) 0.74 ± 0.74 0.89 ± 0.84 0.93 ± 0.88 0.95 ± 0.90 1.11 ± 0.97 — <0.001 Score 0, n (%) 106 (41.7) 191 (35.6) 331 (34.9) 653 (34.7) 923 (30.0) 23.7 <0.001 Score 1, n (%) 112 (44.1) 241 (45.0) 420 (44.3) 798 (42.4) 1243 (40.2) 7.6 0.006 Score ≥ 2, n (%) 36 (14.2) 104 (19.4) 198 (20.9) 429 (22.8) 928 (30.0) 70.5 <0.001 Men AF patients, n 601 1121 1881 3812 6087 Age, median (IQR) 55 (47–65) 57 (48–65) 58 (50–65) 59 (51–66) 60 (52–66) — <0.001 Age ≥ 75, n (%) 33 (5.5) 56 (5.0) 104 (5.5) 261 (6.8) 403 (6.6) 5.7 0.017 Age 65–74, n (%) 124 (20.6) 247 (22.0) 377 (20.0) 826 (21.7) 1554 (25.5) 23.6 <0.001 Time in hospital (d; median, IQR) 9 (7–12) 8 (6–10) 6 (4–7) 4 (3–6) 4 (3–5) — <0.001 Hospital deaths, n (%) — 1 (0.09%) — — 1 (0.02%) — 0.529 Comorbidity, n (%) Heart failure 6 (1.0) 13 (1.2) 14 (0.7) 75 (2.0) 237 (3.9) 68.6 <0.001 Hypertension 223 (37.1) 513 (45.8) 799 (42.5) 1870 (49.1) 3146 (51.7) 73.8 <0.001 Diabetes mellitus 54 (9.0) 147 (13.1) 238 (12.7) 624 (16.4) 1050 (17.2) 46.4 <0.001 Stroke/TIA/TE 18 (3.0) 72 (6.4) 148 (7.9) 181 (4.7) 447 (7.3) 7.7 0.006 Vascular disease 37 (6.2) 102 (9.1) 169 (9.0) 514 (13.5) 992 (16.3) 113.9 <0.001 CHA2 DS2 -VA score (mean ± SD) 0.91 ± 1.08 1.14 ± 1.20 1.11 ± 1.19 1.25 ± 1.24 1.41 ± 1.30 — <0.001 Score 0, n (%) 277 (46.1) 421 (37.6) 711(37.8) 1280(33.6) 1717(28.2) 131.9 <0.001 Score 1, n (%) 171 (28.5) 347 (28.4) 613 (32.6) 1193(31.3) 1940(31.9) 4.4 0.035 Score ≥ 2, n (%) 153 (25.5) 353 (28.9) 557 (29.6) 1339(35.1) 2430(39.9) 124.6 <0.001 CHADS2 score (mean ± SD) 0.61 ± 0.78 0.78 ± 0.88 0.76 ± 0.91 0.84 ± 0.88 0.93 ± 0.93 — <0.001 Score 0, n (%) 321 (53.4) 506 (45.1) 895 (47.6) 1558 (40.9) 2241 (36.8) 111.8 <0.001 Score 1, n (%) 218 (36.3) 425 (37.9) 670 (35.6) 1519 (39.8) 2512 (41.3) 17.6 <0.001 Score ≥ 2, n (%) 62 (10.3) 190 (16.9) 316 (16.8) 735 (19.3) 1334 (21.9) 63.0 <0.001