Transradial versus Transfemoral Access and the Risk of Acute Kidney Injury following Primary Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Propensity-Score-Matched Studies
Table 1
Characteristics of included studies.
Author
Year
Study type
Number of centers
Total population
Total patients with TRA
Total patients with TFA
AKI definition
AKI time lapse
Age mean (SD)
Male sex (%)
Diabetes (%)
CKD (%)
GFR (ml/min/1.73 m2)
Congestive heart failure (%)
Mean LVEF (%) (SD)
Major bleeding (%)
Mean contrast volume ml (SD)
Incidence of AKI (n)
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
TRA
TFA
Cortese
2014
RPSM
4
450
225
225
>0.5 mg/dL or >25%
Highest within 3 days
64.4 (12.5)
64.3 (12.7)
76.40
75.2
22
22
NA
NA
NA
NA
NA
NA
47.3 (9.4)
47.3 (9.4)
NA
NA
193.3 (64.0)
188.3 (69.3)
19
38
Kooiman
2014
RPSM
47
1341
677
664
>0.5 mg/dL
Highest within 7 days
63.9 (11.6)
63.8 (12.1)
69.5
69.6
38.5
38.9
66.6
66.4
81.6 (27.9)
81.2 (27.2)
14.1
15.3
54.1 (11.8)
52.9 (12)
0.8$
2.9$
189.4 (78.1)
191.7 (78.1)
127
172
Kolte
2016
RPSM
2
508
254
254
>0.5 mg/dL or > 25%
Highest within 3 days
60.1 (12.1)
60.6 (12)
70.7
71.1
22
24
2
2
NA
NA
NA
NA
50 (10.4)
50.1 (10.3)
NA
NA
186.1 (63.5)
183.6 (73.5)
14
21
Ando
2017
RCT
78
3952
1977
1975
>0.5 mg/dL or > 25%
Highest during hospitalization
65.5 (11.8)^
65.9 (11.8)^
74.5^
72.6^
22.8^
22.4^
NA
NA
84.2 (25.3)^
83.4 (25.5)^
8.6^
9.2^
NA
NA
NA
NA
183.3 (104.5)^
183.9 (110.1)^
354
397
Marbach
2021
RCT
5
2285
1132
1153
>0.5 mg/dL or > 25%
Highest within 3 days
61.6 (12.2)
61.9 (12.1)
77.8
78.1
16.7
18.3
NA
NA
86.1 (26.9)
86.7 (26.5)
NA
NA
NA
NA
1.6&
2.3&
227.6 (76.7)
232.3 (73.5)
243
226
TRA: transradial access, TFA: transfemoral access, AKI: acute kidney injury, SD: standard deviation, CKD: chronic kidney disease, GFR: glomerular filtration rate, LVEF: left ventricular ejection fraction, RPSM: retrospective propensity score matching sample, and RCT: randomized controlled trial. NA: not available. ∗From the propensity score matching data, no STEMI exclusively. ^From the total population, no STEMI. $Postprocedural bleeding was defined as bleeding within 72 hours after PCI causing a drop in hematocrit >10% and a drop in hemoglobin levels ≥ 3 g/dL, or requiring transfusion of ≥ 1 unit of whole blood. &Bleeding defined based on TIMI bleeding criteria (any major or minor).
