Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention

Figure 1

(a) Table showing median (interquartile range) of ET-1 and Big ET-1 concentrations in the guide catheter (stationed in the aortic root) and coronary sinus pre- and post-PCI. Levels of ET-1 and Big ET-1 increase significantly at both sites following PCI. (b) Histogram showing changes in the trans-myocardial gradient (coronary sinus minus guide catheter levels) of ET-1 pre-and post-PCI: trans-myocardial gradients are neutral at baseline with increased extraction (leftward shift) post-PCI.

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