Rapid Classification and Treatment Algorithm of Cardiogenic Shock Complicating Acute Coronary Syndromes: The SAVE ACS Classification

Table 3

Forward conditional logistic regression analysis determining main independent “frontline” predictors of 30-day mortality.

		OR (95% CI)	value	AUC C-statistic	value
Model 1	Lactate	1.55 (1.42 to 1.69)	<0.001	0.787 (0.745 to 0.828)	<0.001
Model 2	Lactate	1.46 (1.34 to 1.6)	<0.001	0.830	<0.001
	Intubated	6.09 (3.9 to 9.6)	<0.001	0.793 to 0.867)
Model 3	Lactate	1.48 (1.35 to 1.62)	<0.001	0.858 (0.825 to 0.891)	<0.001
	Intubated	9.74 (5.8 to 16.33)	<0.001
	Age	1.06 (1.04 to 1.08)	<0.001
Model 4	Lactate	1.28 (1.15 to 1.43)	<0.001	0.868 (0.837 to 0.900)	<0.001
	Intubated	9.35 (5.55 to 15.74)	<0.001
	Age	1.06 (1.04 to 1.08)	<0.001
	BE	1.11 (1.05 to 1.17)	<0.001
Model 5	Lactate	1.27 (1.13 to 1.42)	<0.001	0.878 (0.850 to 0.907)	<0.001
	Intubated	78.34 (4.89 to 14.2)	<0.001
	Age	1.05 (1.04 to 1.07)	<0.001
	BE	1.11 (1.05 to 1.17)	<0.001
	LVEF-mild/N	REF
	LVEF-mod	1.88 (1.21 to 3.16)	0.017
	LVEF-severe	2.18 (1.28 to 3.75)	0.004
Model 6	Lactate	1.25(1.12 to 1.41)	<0.001	0.879 (0.851 to 0.908)	<0.001
	Intubated	7.4 (4.3 to 12.74)	<0.001
	Age	1.05 (1.04 to 1.07)	<0.001
	BE	1.10 (1.04 to 1.17)	<0.001
	LVEF-mild/N	REF
	LVEF-mod	1.84 (1.09 to 3.1)	0.022
	LVEF-severe	1.98 (1.14 to 3.42)	0.015
	SBP	0.99 (0.982 to 0.999)	0.024

N = 892 patients included in the analysis. J: variables included in the regression model: age, gender, cardiac arrest, ongoing resuscitation on admission, ECG on admission, intubated/ventilated on admission, LVEF category, SBP, pH, lactate, and BE, statistically significant increase in the AUC when compared to previous model, OR: odds ratio, CI: confidence interval, AUC: area under the curve, BE: base excess, LVEF: left ventricular ejection fraction, SBP: systolic blood pressure, and ECG: electrocardiogram.