| | | No PH (n = 61) | Improved PH (n = 35) | Persistent or new-onset PH (n = 28) | value |
| | Age (years) | 78 ± 7 | 81 ± 7 | 79 ± 9 | 0.149 | | Male sex, n (%) | 31 (50.0%) | 17 (27.4%) | 14 (22.6%) | 0.892 | | BMI (kg/m2) | 24.57 (22.57, 27.39) | 22.10 (21.37, 24.63) | 23.96 (20.17, 26.72) | 0.068 | | Medical history | | HT, n (%) | 41 (67.2%) | 23 (62.2%) | 17 (60.7%) | 0.796 | | DM, n (%) | 19 (31.1%) | 11 (29.7%) | 6 (21.4%) | 0.630 | | CHD, n (%) | 19 (31.1%) | 13 (35.1%) | 9 (32.1%) | 0.919 | | AF, n (%) | 7 (11.5%) | 7 (18.9%) | 7 (25.0%) | 0.257 | | Clinical characteristics | | SBP (mmHg) | 138 ± 23 | 133 ± 24 | 135 ± 22 | 0.547 | | DBP (mmHg) | 75 ± 13 | 71 ± 15 | 73 ± 11 | 0.279 | | HR (bpm) | 76 ± 16 | 83 ± 18 | 79 ± 17 | 0.104 | | FPG (mmol/L) | 5.33 (4.67, 8.02) | 5.59 (4.84, 7.36) | 5.38 (5.00, 7.00) | 0.916 | | WBC (×109/L) | 6.77 ± 0.33 | 6.26 ± 0.32 | 7.49 ± 0.55 | 0.150 | | RBC (×1012/L) | 4.12 ± 0.08 | 4.01 ± 0.10 | 3.97 ± 0.15 | 0.504 | | HB (g/L) | 125.62 ± 2.22 | 122.26 ± 3.13 | 117.46 ± 4.82 | 0.196 | | PLT (×109/L) | 191.45 ± 6.70 | 166.71 ± 8.77 | 199.43 ± 14.05 | 0.059 | | RDW_SD (fL) | 43.40 (41.40, 45.85) | 45.60 (43.10, 50.90) | 47.35 (43.00, 52.40) | 0.001 | | RDW_CV | 0.13 (0.12, 0.14) | 0.13 (0.13, 0.14) | 0.14 (0.13, 0.16) | 0.001 | | MPV (fL) | 10.50 (9.90, 11.20) | 10.80 (9.90, 11.80) | 10.90 (10.23, 11.20) | 0.274 | | PDW (fL) | 12.43 ± 2.31 | 13.26 ± 2.65 | 12.70 ± 2.11 | 0.262 | | NEUT (×109/L) | 4.05 (3.21, 5.50) | 4.32 (3.58, 5.69) | 4.60 (3.79, 7.02) | 0.295 | | LYM (×109/L) | 1.73 ± 0.91 | 1.25 ± 0.65 | 1.30 ± 0.75 | 0.008 | | NLR | 2.74 (1.67, 4.29) | 3.48 (2.54, 5.68) | 5.78 (2.09, 8.89) | 0.024 | | PLR | 65.21 (43.58, 111.22) | 46.56 (29.18, 63.39) | 37.99 (18.41, 96.35) | 0.017 | | ALT (U/L) | 16.00 (11.00, 25.50) | 23.00 (11.00, 40.50) | 27.00 (17.00, 37.00) | 0.181 | | AST (U/L) | 19.00 (16.00, 25.25) | 28.00 (19.00, 46.00) | 27.00 (19.00, 37.00) | 0.008 | | T-BIL (umol/L) | 12.44 ± 1.01 | 16.87 ± 2.53 | 15.80 ± 1.41 | 0.028 | | r-GT (U/L) | 21.00 (14.00, 34.75) | 33.00 (18.80, 63.50) | 31.50 (25.50, 40.00) | 0.107 | | TP (g/L) | 65.75 ± 1.85 | 64.71 ± 1.58 | 69.37 ± 2.55 | 0.246 | | ALB (g/L) | 39.10 (37.20, 41.20) | 39.00 (37.55, 40.40) | 40.10 (37.28, 42.13) | 0.370 | | TC (mmol/l) | 4.71 ± 1.21 | 4.53 ± 1.21 | 4.70 ± 1.12 | 0.783 | | TG (mmol/l) | 1.25 (0.88, 1.64) | 0.95 (0.77, 1.29) | 0.94 (0.76, 1.53) | 0.065 | | HDL-C (mmol/l) | 1.15 ± 0.36 | 1.08 ± 0.27 | 1.15 ± 0.28 | 0.560 | | LDL-C (mmol/l) | 2.58 ± 0.83 | 2.55 ± 0.89 | 2.60 ± 0.83 | 0.981 | | UA (mmol/L) | 340 ± 109 | 416 ± 204 | 416 ± 161 | 0.025 | | Scr (μmol/l) | 72 (64, 86) | 73 (63, 129) | 79 (63, 117) | 0.436 | | eGFR (ml/min/1.73 m2) | 84.56 ± 29.45 | 77.45 ± 36.32 | 71.01 ± 36.61 | 0.188 | | BNP (ng/L) | 300 (131, 937) | 1923 (523, 3164) | 1015 (379, 2172) | <0.001 | | Hs-cTnI (μg/L) | 0.06 (0.19, 0.35) | 0.13 (0.06, 0.39) | 0.11 (0.02, 0.53) | 0.247 | | Baseline echocardiographic data | | RVD (mm) | 17 ± 2 | 18 ± 2 | 17 ± 2 | 0.078 | | LAVI (ml/m2) | 31.45 ± 9.15 | 40.26 ± 10.56 | 39.74 ± 13.16 | <0.001 | | LVMI (g/m2) | 129 (112, 153) | 149 (120, 180) | 144 (114, 163) | 0.350 | | LVEF (%) | 58 (48, 58) | 48 (37, 55) | 55 (49, 58)# | 0.002 | | E/e′ ratio | 15 ± 6 | 20 ± 8 | 20 ± 7 | 0.004 | | AV velocity (m/s) | 4.48 ± 0.84 | 4.75 ± 1.12 | 4.81 ± 0.82 | 0.191 | | Peak AV pressure (mmHg) | 83.53 ± 28.09 | 95.54 ± 40.49 | 95.79 ± 30.58 | 0.130 | | Average AV pressure (mmHg) | 50.33 ± 17.00 | 58.66 ± 26.18 | 58.04 ± 21.06 | 0.111 | | PAD (mm) | 23 (21, 25) | 24 (22, 26) | 25 (23, 27) | 0.024 | | RVSP (mm) | — | 55 ± 14 | 51 ± 8 | 0.166 |
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PH, pulmonary hypertension; BMI, body mass index; HT, hypertension; DM, diabetes mellitus; CHD, coronary heart disease; AF, atrial fibrillation; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR heart rate; FPG, fast plasma glucose; WBC, white blood cell count; RBC, red blood cell count; HB, hemoglobin; PLT, platelet; RDW_SD, the red cell distribution width_Standard Deviation; RDW_CV, the red cell distribution width_Coefficient of Variation; MPV, mean platelet volume; PDW, platelet distribution width; NEUT, neutrophil count; LYM, lymphocyte count; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-lymphocyte-ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; T-BIL, serum total bilirubin; r-GT, r-glutamyltranspeptidase; TP, total protein; ALB, albumin; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; UA, uric acid; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; BNP, B-type natriuretic peptide; hs-cTnI, high-sensitivity troponin C; RVD, right ventricular diastolic diameter; LAVI, left atrial volume index; LVMI, left ventricular mass index; LVEF, left ventricular ejection fraction; E/ e′, early diastolic transmitral flow velocity/lateral mitral annular myocardial velocity; AV, aortic valve; PAD, pulmonary artery diameter; RVSP, right ventricular systolic pressure. , vs. Group I; #, vs. Group II. , vs. Group I. The bold values indicate statistical significances ( ) among the three groups. |
