Meta-Analysis of Randomized Trials: Efficacy and Safety of Colchicine for Secondary Prevention of Cardiovascular Disease

Table 3

Safety outcomes.

Outcome	Studies	Participants	Statistical method	Effect estimate
GI adverse reactions	6	11575	Odds ratio (Peto, fixed, 95% CI)	1.06 [0.94, 1.20]
Treatment discontinuation	6	11575	Odds ratio (Peto, fixed, 95% CI)	1.11 [0.96, 1.28]
Infections	2	10198	Odds ratio (Peto, fixed, 95% CI)	1.04 [0.84, 1.28]
Myalgia	4	4683	Odds ratio (Peto, fixed, 95% CI)	1.16 [0.99, 1.36]
Cancer	2	10198	Odds ratio R (Peto, fixed, 95% CI)	0.97 [0.78, 1.21]
Myelotoxicity	6	11307	Odds ratio OR (Peto, fixed, 95% CI)	1.01 [0.56, 1.80]