Review Article
Lipid Abnormalities and Cardiometabolic Risk in Patients with
Overt and Subclinical Thyroid Disease
Table 1
Changes in enzyme activities, transfer proteins, and receptors involved in lipid metabolism induced by thyroid hormones.
| Enzymes, transfer proteins, and liver receptors | Thyroid hormone effect |
| 3-hydroxy-3-methyl-glutaryl coenzyme A reductase | ↑ | Adipose lipoprotein lipase | Usually normal (may be ↓ in hypothyroidism) | Hepatic lipase | ↑ | Cholesteryl ester transfer protein | ↑ | ATP-binding cassette transporter A1 | ↓ | Acetyl-CoA carboxylase 1 | ↑ | Carnitine palmitoyltransferase Ia | ↑ | 7alpha-hydroxylase | ↓ | LDL receptor | ↑ |
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