C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing
Figure 3
The effects of treatments on the SL profile. (a)–(c) Total ceramides, DHceramides, and other SLs, respectively. The data are expressed as fold changes, that is, ratios of treated versus controls (Pc 4 alone and untreated controls) and are shown as average ± SEM from four independent determinations. For other details, refer to Figure 2 legend. The significance () is shown as follows: * indicates the significant difference between an individual treatment, LCL30 or PDT, and the combination (PDT+LCL30); ~ indicates the significant difference between LCL30 and PDT. DHSph, dihydrosphingosine; Sph, sphingosine.
