C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing
Figure 5
DEVDase activation is enhanced after (PDT+LCL30). Following incubations (see Figure 2 legend), cells were collected, cell lysates were prepared, and DEVDase activity was measured using DEVD-AMC as the fluorogenic substrate. The data are expressed as fold changes, that is, ratios of treated versus untreated controls and are shown as average ± SEM from four to six independent determinations. The significance () is shown by an asterisk indicating significant difference between an individual treatment, LCL30 or PDT, and the combination (PDT+LCL30).
