C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing

Table 1

The effect of LCL30, PDT, and PDT + LCL30 on the SL profile in SCCVII cells.

	LCL30	PDT	PDT + LCL30
	Sphingolipids^a
C14-Cer	1.35	0.90	1.33
C16-Cer	1.02	1.13	1.53
C18-Cer	1.18	1.52	1.70
C18:1-Cer	1.12	1.19	1.48
C20-Cer	1.13	1.53	1.69
C20:1-Cer	1.64	1.65	2.06
C22-Cer	0.82	1.43	1.42
C22:1-Cer	1.23	1.11	1.41
C24-Cer	0.82	1.07	1.19
C24:1-Cer	1.09	1.09	1.37
C26-Cer	0.94	1.39	1.05
C26:1-Cer	0.77	1.46	1.46
C14-DHCer	0.71	1.60	1.64
C16-DHCer	0.72	1.52	1.22
C18-DHCer	0.67	1.25	1.00
C20-DHCer	0.96	1.30	1.40
C22-DHCer	0.97	1.90	1.70
C22:1-DHCer	1.20	1.73	2.28
C24-DHCer	0.67	1.16	1.14
C24:1-DHCer	0.99	1.36	1.51
DHSph	0.71	0.59	0.25
Sph	1.00	0.05	0.05
S1P	1.63	0.14	0.56

^aThe data are shown as ratios compared to controls (untreated and Pc 4 alone). Significant values at 𝑃<.05 are shown in bold. C14-Cer, C14-ceramide, and so forth; C14-DHCer, C14-dihydroceramide, and so forth; DHSph, dihydrosphingosine; Sph, sphingosine.