Research Article
Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues
Figure 4
Synthetic route to the aCDase inhibitors DP24 a–c and DP25 a,c. Reagents and conditions: (i) triethylamine, r.t., 2–6 hrs; (ii) H2, Pd/C, methanol, r.t., 16 hrs; (iii) myristoyl chloride, pyridine, 4 hrs; (iv) tetradecyl isocyanate, acetonitrile/chloroform, r.t. 6 hrs.
