Sphingosine 1-Phosphate Distribution in Human Plasma: Associations with Lipid Profiles
Table 3
(a) Concentrations of sphingoid bases and their 1-phosphates in plasma. (b) Concentrations of sphingoid bases and their 1-phosphates in lipoprotein-containing fraction ( g/mL ultracentrifuge fraction). (c) Concentrations of sphingoid bases and their 1-phosphates in plasma protein-containing fraction ( g/mL ultracentrifuge fraction).
(a)
Subject
Concentration (nM)
dhSph
dhS1P
Sph
S1P
1
13
157
8
939
2
19
114
19
1072
3
10
132
18
884
4
14
138
20
913
5
7
171
23
1272
6
19
147
24
1132
(b)
Subject
Concentration (nM)
S1P normalized to HDL-C
dhSph
dhS1P
Sph
S1P
(nmole/mmole)
1
6
33
11
669
32
2
19
21
15
710
51
3
4
31
9
595
28
4
3
34
11
523
48
5
17
26
12
696
58
6
19
12
18
442
63
(c)
Subject
Concentration (nM)
dhSph
dhS1P
Sph
S1P
S1P in plasma protein fraction (%)
1
7
105
7
248
27
2
8
133
8
571
45
3
8
111
10
263
31
4
7
79
10
215
34
5
11
150
7
555
44
6
8
117
19
919
63
Sph: sphingosine, dhSph: dihydrosphingosine, their 1-phosphates S1P and dhS1P.