8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice

Figure 1

Changes in hepatic gene expression (a) and in concentrations of long-chain saturated fatty acids (b) in male C57BL/6J-DIO mice fed HFD, HFD with EPA, or HFD with 8-HEPE for 4 wk. Gene expression levels were measured by real-time PCR and normalized against expression of Actb. Values are means ± SDs, . Labeled means without a common letter differ; . HFD: high-fat diet; HEPE: hydroxyeicosapentaenoic acid; EPA: eicosapentaenoic acid.

(a)

(b)