8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice

Table 1

Body weights, liver weights, the relative amount of gonadal WAT per g body weight in male C57BL/6J-DIO mice fed HFD, HFD with EPA, HFD with 8-HEPE, LFD, LFD with EPA, or LFD with 8-HEPE for 4 wk. Values are means ± SDs, . Labeled means without a common letter differ; . HFD: high-fat diet; LFD: low-fat diet; HEPE: hydroxyeicosapentaenoic acid; EPA: eicosapentaenoic acid.

	Body weight (g)	Liver weight (g)	Gonadal WAT per g body weight (%)
HFD	35.96 ± 2.19	1.28 ± 0.13	5.94 ± 0.61
HFD with EPA	35.92 ± 2.95	1.26 ± 0.13	5.85 ± 1.13
HFD with 8-HEPE	35.09 ± 1.27	1.29 ± 0.10	5.74 ± 0.39
LFD	26.02 ± 1.17	0.96 ± 0.22	2.16 ± 0.40
LFD with EPA	25.42 ± 3.64	1.02 ± 0.14	2.71 ± 0.66
LFD with 8-HEPE	26.10 ± 1.46	1.00 ± 0.12	2.36 ± 0.48